The primary function of Histopathological Core includes hassle-free access to well-maintained, state-of-the-art tissue processing equipment. The core also provides PI's and their staff with training in tissue processing and advanced staining techniques. Protocols for the latter are collected, and collated electronically in a shared database accessible to all Faculty members and COBRE investigators.
The Histopathology Core will support the faculty and COBRE projects by facilitating the rapid phenotypic analysis of transgenic or null mice. This core will do histopathological and immuno-cytochemistry analysis of livers and serum chemistry of null mice, compared to control mice, as well as under different conditions (diet, drugs, etc).
Other functions of the core include determining gross histological characteristics of tissue, measuring and localizing protein and gene expression in liver or other tissues by immunocytochemistry or in situ hybridization techniques, and performing serum chemistry analysis to follow liver injury and repair during studies of fibrogenesis or fatty liver.
The core is on a service charge system, and the income is used to maintain core lab such as reagents ordering and instrument maintenance.
All Histopathology Core instruments are located in 4044 Hemenway Life Sciences Innovation Center. This lab is open from 7:00 a.m. to 6:00 p.m. Monday through Friday, excluding holidays.
Training from Huina Cai is required before using instrument. Please contact Huina Cai to arranage a time for training. Once trained, you will schedule instrument time via the Pharmacology, Toxicology SharePoint site.
Wen-Xing Ding, Ph.D
Histopathology Core Technician