The Analytical Core supports the investigators of the COBRE projects by providing instrumentation and expertise in its application to research problems. Specifically, the Analytical Core provides and promote HPLC, LC-MS/MS, Multi-mode spectrophotometry and real-time PCR as analytical tools available to our investigators. This Core provides COBRE investigators with modern instrumental approaches for the isolation, identification, and quantification of compounds of relevance to their studies of liver function in health and disease. It validates instrument performance as a component of an overall quality assurance program for this core facility. This Core assists and trains COBRE investigators in appropriate sampling and sample preparation to take advantage of these instrumental approaches.